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                                  10734117 Apparatuses and methods for determining a patient's response to multiple cancer drugs  
                                  Apparatuses (including devices and systems) and methods for determining if a patient will respond to a variety of cancer drugs.
                                  10732184 Diagnosis of cancer by detecting auto-antibodies against PAR1  
                                  The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against protease-activated receptor 1 (PAR1) in a sample from a...
                                  10732182 Method for predicting cancer sensitivity  
                                  The present invention relates to methods of determining cancer cell sensitivity to treatment by using antibodies that specifically bind to and detect the presence of a Bcl-2 heterodimer protein,...
                                  10731224 Enhancement of cancer screening using cell-free viral nucleic acids  
                                  Cell-free DNA molecules in a mixture of a biological sample can be analyzed to detect viral DNA. Methylation of viral DNA molecules at one or more sites in the viral genome can be determined....
                                  10731221 Diagnosing IDH1 related subgroups and treatment of cancer  
                                  The invention relates to classification, diagnosis and treatment of cancers. In one embodiment, the present invention provides methods and kits that classify cancers into various subtypes based on...
                                  10731162 Methods relating to circulating tumor cell clusters and the treatment of cancer  
                                  Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic subpopulation of CTCs. In some...
                                  10731134 Production method for artificial cancer stem cell and induced differentiation method therefor  
                                  It is intended to provide a cancer stem cell and a method for preparing the same. The present invention provides a method for preparing a pluripotent cancer stem cell, comprising transferring...
                                  10731128 Compositions and methods for in vitro activation and expansion of serial killer T cell populations and passive immunization of a cancer patient with tumor cell killing cells  
                                  The described invention provides a method for in vitro immunoactivation of mononuclear cells by contact with one or more populations of engineered leukocyte stimulator cells genetically engineered...
                                  10730903 Adenosine analogs as methyltransferase inhibitors for treating cancer  
                                  Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structures The compounds disclosed are useful in the treatment of cancer and similar diseases...
                                  10730840 Substituted tetrahydroisoquinoline ethylbenzamide anti-cancer agents  
                                  The compounds herein disclosed are N-substituted tetrahydroisoquinoline ethylbenzamide compounds that have modifications on the phenyl rings by introducing groups with various electronic...
                                  10729766 Method for improving the efficacy of a survivin vaccine in the treatment of cancer  
                                  The present invention provides methods for improving the efficacy of a vaccine in the treatment of cancer. The methods of the invention comprise the administration of at least two doses of an...
                                  10729755 Peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers  
                                  The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
                                  10729752 Compositions and methods for treating cancer with arginine depletion and immuno oncology agents  
                                  Methods of treating tumors or cancer include administration of an arginine depleting enzyme and an immune-oncology agent.
                                  10729739 Methods of treating prostate cancer with GnRH antagonist  
                                  The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a...
                                  10729713 Pharmaceutical composition for treating hepatitis, liver fibrosis, and liver cancer  
                                  The present invention relates to a pharmaceutical composition for treating hepatitis, liver fibrosis, and liver cancer, which comprises the following components in parts by weight: 0.15-10 parts...
                                  10729699 Methods of treating castration-resistant prostate cancer with glucocorticoid receptor antagonists after anticancer therapy  
                                  Embodiments of the invention are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor...
                                  10729692 Dual inhibition of CDK and HSP90 destabilize HIF1alpha and synergistically induces cancer cell death  
                                  The present disclosure provides pharmaceutical compositions including a CDK inhibitor and an HSP90 inhibitor, as well as methods of treating cancer or a tumor in a subject by administering a CDK...
                                  10729689 Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents  
                                  A series of novel EHop-016 derivatives is presented herein via designing and synthesizing compounds that mimics its more favorable “U-shaped” conformation that appears to be critical for...
                                  10729671 Zinc complexes of hydrazones and (thio)semicarbazones and their use for the treatment of cancer  
                                  The invention provides complexes of Zn2+ of formulae (la) and (IIa) that are useful for treating cancer, as well as compositions and kits comprising such complexes.
                                  10729669 Compositions and methods for treating cancer  
                                  The invention provides compositions and methods to treat a hyperproliferative disorder with phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof and an anti-cancer composition.
                                  10725053 Prostate cancer-associated secreted proteins  
                                  Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate...
                                  10725051 Multiplex MRM assay for evaluation of cancer  
                                  The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (ER), progesterone receptor (PR), and/or antigen Ki67 (Ki67)...
                                  10725045 Quantifying MGMT protein for optimal cancer therapy of glioblastoma  
                                  Methods are provided for treating a cancer patient suffering from a glioblastoma (GBM) by administering to the patient an effective amount of temozolomide, wherein a mass spectrometry analysis of...
                                  10725042 Methods of diagnosing and treating cancer  
                                  A method of determining the susceptibility of a cancer in a subject to treatment with an antimetabolite includes obtaining a sample of cancer cells from the subject, measuring the level of UDG...
                                  10725023 Method of measuring cell-substrate impedance in living cells to identify compounds affecting receptor tyrosine kinase (RTK) activity and pathways for the treatment of cancer  
                                  A method of identifying a therapeutic compound for treating cancer in a human subject, the method including: providing a device that measures cell-substrate impedance; culturing cancer cells in...
                                  10724102 Point mutations in TRK inhibitor-resistant cancer and methods relating to the same  
                                  Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment...
                                  10724101 Biomarker SCNN1B for gastric cancer  
                                  The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the SCNN1B gene, which in some cases is due to...
                                  10724100 Systems and methods for treating patients having a genetic predisposition to develop prostate cancer  
                                  Systems and methods for mitigating prostate cancer development are provided. Peripheral blood cells may be evaluated for the presence or quantity of gamma-H2AX foci, and/or for gene alterations...
                                  10723756 Cyclic dinucleotides for treating conditions associated with STING activity such as cancer  
                                  This disclosure features chemical entities (e.g., a compound that modulates (e.g., agonizes) Stimulator of Interferon Genes (STING), or a pharmaceutically acceptable salt, and/or hydrate, and/or...
                                  10723748 Monomaleimide-functionalized platinum compounds for cancer therapy  
                                  The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin...
                                  10722600 Methods and compositions for treating cancer  
                                  The present invention relates to the use of NS1/2 region of murine norovirus MNV or a corresponding region from a member of the Caliciviridae family or a protein encoded by any one of those...
                                  10722593 Anti-cancer compounds and conjugates thereof  
                                  Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The...
                                  10722538 Peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers  
                                  The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
                                  10722537 Activation of resident memory T cells for cancer immunotherapy  
                                  Provided herein are methods of treating cancer by activating resident memory T cells using one or more antigenic peptides.
                                  10722531 OPRT expression and cancer treatment outcome  
                                  Improved methods for treating cancer are provided herein by determining if a cancer patient, particularly a colon cancer patient or a gastric cancer patient, will clinically respond in a favorable...
                                  10722530 Methods of diagnosing and treating cancer  
                                  A method of treating cancer in a subject includes determining the p53 status and the level of UDG in cancer cells of the subject and administering an antimetabolite agent in combination with an AP...
                                  10722523 Chemoimmunotherapy for epithelial cancer  
                                  The invention provides a method for treating cancer in a subject in need thereof, wherein said subject comprises cancer tissue that ‘contains epithelial cancer cells and immunosuppressive 8 cells,...
                                  10722515 Dual CLK/CDK1 inhibitors for cancer treatment  
                                  The disclosure generally relates to substituted purine analogs that are dual CLK2/CDK1 inhibitors or more potent and specific CLK inhibitors to target CLK2 and CDK1 kinases. These compounds may be...
                                  10722484 Methods of cancer treatment  
                                  This present disclosure is directed to a method of treating a subject with cancer with a combination of a protein kinase C (PKC) activator and a second therapeutic agent.
                                  10722480 Agent for controlling cells constituting cancer microenvironment or inflammatory microenvironment  
                                  An agent according to the present invention comprises as an effective component any of (1) disulfiram, diethyldithiocarbamate, or a metal complex of diethyldithiocarbamate; (2) a pharmaceutically...
                                  10722466 Liposomal formulation for use in the treatment of cancer  
                                  The invention relates to a pharmaceutical liposomal composition comprising 2-{[5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy ]phenyl}-6-(4-fluorophenyl)thieno...
                                  10718774 Methods and compositions for assessing germline risk of cancer  
                                  Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers. In response to DNA breaks, the...
                                  10718030 Methods for predicting effectiveness of chemotherapy for a breast cancer patient  
                                  The present invention relates to a method of predicting the effectiveness of chemotherapy in a breast cancer patient, and more particularly, to a method for predicting the effectiveness of...
                                  10717780 Agents for treatment of claudin expressing cancer diseases  
                                  The present invention provides binding agents that contain n binding domain that is specific for CD3 allowing binding to T cells and a binding domain that is specific for a tumor-associated...
                                  10717724 Compounds useful for treating cancer  
                                  The present invention relates to a compound of formula (I): wherein A and A′ independently represent a phenylene group or a pyridylene group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is a...
                                  10717722 Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer  
                                  The aryl sulfonamide compounds of this invention have powerful and cell-type specific Bcl inhibitory activity. Compounds of this invention include compounds according to formula (I): Selected...
                                  10716868 Imaging of metastatic or recurrent cancer  
                                  The present disclosure relates to methods of administering [18F]-FACBC. The present disclosure also relates to use of [18F]-FACBC in methods for imaging, diagnosing and monitoring metastasis or...
                                  10716861 Composition intended to vectorise an anti-cancer agent  
                                  A composition in the form of a water-in-oil emulsion comprising: from 20% to 40% (v/v) of aqueous phase, in the form of droplets, comprising an anti-cancer agent and a densifying agent chosen from...
                                  10716837 Methods and compositions relating to P62 for the treatment and prophylaxis of cancer  
                                  Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer...
                                  10716826 Compositions for overcoming anti-cancer drug-resistance or compositions for anti-cancer activity employing CAGE-derived peptides  
                                  A pharmaceutical anticancer or anticancer drug-resistance composition for a cancer cell, containing a CAGE-derived peptide, is provided. The pharmaceutical anticancer composition contains an...

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